Elston–Stewart algorithm

Efficient computation of the joint probability of multiple inherited risk alleles from pedigree data

The Elston–Stewart peeling algorithm enables estimation of an individual's probability of harboring germline risk alleles based on pedigree data, and serves as the computational backbone of important genetic counseling tools. However, it remains …

Germline Mutation Detection in Next Generation Sequencing Data and TP53 Mutation Carrier Probability Estimation for Li-Fraumeni Syndrome

Next generation sequencing technology has been widely used in genomic analysis, but its application has been compromised by the missing true variants, especially when these variants are rare. We proposed a family-based variant calling method, FamSeq, …